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| Cat.No | ACP00645 | Target Name | PAIP2 |
|---|---|---|---|
| Target Synonyms | PABP-interacting protein 2;PAIP-2;PolyA | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 1-127aa |
| Mol Weight | 16.8 kDa | Protein Length | Full length |
| Purity | Greater than 95% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BPZ3 |
|---|
Uniprot Id
Q9BPZ3
Target Species
Human
Target Name
PAIP2
Target Full Name
Polyadenylate-binding protein-interacting protein 2
Target Function
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Target Subcellular Location
Cytoplasm.
Target Protein Families
PAIP2 family
Target Tissue Specificity
Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
PABP-interacting protein 2; PAIP-2; PAIP2; PAIP2_HUMAN; poly(A) binding protein interacting protein 2; Poly(A)-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2
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