Recombinant Human Polycystin-1 (PKD1), Truncated

Cat.No	ACP05332	Target Name	PKD1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05332

Target Name

PKD1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P98161

Background Information

Uniprot Id

P98161
Target Species

Human
Target Name

PKD1
Target Full Name

Polycystin-1
Target Function

Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity. Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
Target Involvement

Polycystic kidney disease 1 (PKD1)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Endoplasmic reticulum. Golgi apparatus.
Target Protein Families

Polycystin family
Target Research Area

Cancer
Target Synonyms

Autosomal dominant polycystic kidney disease 1 protein; Autosomal dominant polycystic kidney disease protein 1; nPKC-D1; nPKC-mu; OTTHUMP00000208669; OTTHUMP00000208670; PBP; Pc-1; PKD; Pkd1; PKD1_HUMAN; Polycystic Kidney Disease 1; polycystic kidney disease-associated protein; Polycystin 1 Precursor; Polycystin-1; Protein kinase C mu type; Protein kinase D; Serine/threonine-protein kinase D1; transient receptor potential cation channel; subfamily P; member 1; TRPP1

Recombinant Human Polycystin-1 (PKD1), Truncated

Specifications

Immunogen Information

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