Recombinant Human Polypyrimidine tract-binding protein 2 (PTBP2)

Uniprot Id

Q9UKA9

Target Species

Human

Target Name

PTBP2

Target Full Name

Polypyrimidine tract-binding protein 2

Target Function

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.; Reduced affinity for RNA.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform

Target Synonyms

brPTB; FLJ34897; MIBP; Neural polypyrimidine tract binding protein; Neural polypyrimidine tract-binding protein; Neurally enriched homolog of PTB; Neurally-enriched homolog of PTB; nPTB 5; nPTB 6; nPTB 7; nPTB 8; nPTB; nPTB5; nPTB6; nPTB7; nPTB8; Polypyrimidine tract binding protein 2; Polypyrimidine tract-binding protein 2; PTB; PTB like; PTB like protein; PTB-like protein; PTBLP; PTBP 2; Ptbp2; PTBP2_HUMAN; Splicing regulator

Target Background

The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants.