Recombinant Human Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1)

Cat.No	ACP13842	Target Name	CLP1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-425	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13842

Target Name

CLP1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-425

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q92989

Background Information

Uniprot Id

Q92989
Target Species

Human
Target Name

CLP1
Target Full Name

Polyribonucleotide 5'-hydroxyl-kinase Clp1
Target Function

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing
Target Involvement

Pontocerebellar hypoplasia 10 (PCH10)
Target Subcellular Location

Nucleus.
Target Protein Families

Clp1 family, Clp1 subfamily
Target Synonyms

ATP/GTP binding protein; Cleavage and polyadenylation factor I subunit 1; CLP 1; clp1; CLP1 cleavage and polyadenylation factor I subunit homolog; CLP1; cleavage and polyadenylation factor I subunit; homolog (S. cerevisiae); CLP1; yeast; homolog of; CLP1_HUMAN; hClp1; Homolog of yeast CFIA subunit Clp1p; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Polyribonucleotide 5' hydroxyl kinase Clp1; Polyribonucleotide 5''-hydroxyl-kinase Clp1; Pre mRNA cleavage complex II protein Clp1; Pre-mRNA cleavage complex II protein Clp1

Recombinant Human Polyribonucleotide 5′-hydroxyl-kinase Clp1 (CLP1)

Specifications

Immunogen Information

Inquire Recombinant Human Polyribonucleotide 5′-hydroxyl-kinase Clp1 (CLP1) Now

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