Recombinant Human Potassium channel subfamily K member 10 (KCNK10), Truncated

Uniprot Id

P57789

Target Species

Human

Target Name

KCNK10

Target Full Name

Potassium channel subfamily K member 10

Target Function

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Two pore domain potassium channel (TC 1.A.1.8) family

Target Tissue Specificity

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Target Synonyms

KCNK10; TREK2; Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+ channel subunit

Target Background

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.