Recombinant Human POU domain, class 2, transcription factor 3 (POU2F3)

Uniprot Id

Q9UKI9

Target Species

Human

Target Name

POU2F3

Target Full Name

POU domain, class 2, transcription factor 3

Target Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.

Target Subcellular Location

Nucleus.

Target Protein Families

POU transcription factor family, Class-2 subfamily

Target Tissue Specificity

Specifically expressed in epidermis and cultured keratinocytes.

Target Research Area

Others

Target Synonyms

class 2; Epoc 1; Epoc1; HGNC19864; Oct 11; Oct-11; OCT11; Octamer binding transcription factor 11; Octamer-binding protein 11; Octamer-binding transcription factor 11; OTF-11; PLA 1; PLA1; PLA1 protein ; PO2F3_HUMAN; POU class 2 homeobox 3; POU domain; POU domain transcription factor OCT11a; POU domain, class 2, transcription factor 3; POU transcription factor; POU2F3; Skn 1a; transcription factor 3; Transcription factor PLA-1; Transcription factor Skn-1; Transcription factor Skn1

Target Background

This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.