Recombinant Human Pre-mRNA-splicing factor ISY1 homolog (ISY1)

Uniprot Id

Q9ULR0

Target Species

Human

Target Name

ISY1

Target Full Name

Pre-mRNA-splicing factor ISY1 homolog

Target Function

Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an intermediate state of poised pluripotency, which precedes transition to the primed state. Involved in pre-mRNA splicing as component of the spliceosome

Target Subcellular Location

Nucleus.

Target Protein Families

ISY1 family

Target Synonyms

FSAP33; ISY1; ISY1 splicing factor homolog (S. cerevisiae); ISY1_HUMAN; KIAA1160; Pre-mRNA-splicing factor ISY1 homolog

Target Background

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type catalytic step 1 spliceosome and catalytic step 2 spliceosome.