Recombinant Human Prickle-like protein 1 (PRICKLE1), Truncated

Uniprot Id

Q96MT3

Target Species

Human

Target Name

PRICKLE1

Target Full Name

Prickle-like protein 1

Target Function

Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.

Target Involvement

Epilepsy, progressive myoclonic 1B (EPM1B); Neural tube defects (NTD)

Target Subcellular Location

Nucleus membrane. Cytoplasm, cytosol. Note=A smaller amount is detected in the cytosol.

Target Protein Families

Prickle / espinas / testin family

Target Tissue Specificity

Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).

Target Synonyms

PRICKLE1; RILPPrickle-like protein 1; REST/NRSF-interacting LIM domain protein 1