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| Cat.No | ACP00313 | Target Name | PRICKLE2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 558-844aa | Mol Weight | 37.9 |
| Protein Length | Partial | Purity | Greater than 95% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7Z3G6 |
|---|
Uniprot Id
Q7Z3G6
Target Species
Human
Target Name
PRICKLE2
Target Full Name
Prickle-like protein 2
Target Involvement
PRICKLE2 mutations have been found in patients with myoclonic epilepsy but involvement of this gene in pathogenesis is under debate since some of the patients also carry POLG mutations.
Target Subcellular Location
Nucleus membrane.
Target Protein Families
Prickle / espinas / testin family
Target Tissue Specificity
Expressed in brain, eye and testis. Additionally in fetal brain, adult cartilage, pancreatic islet, gastric cancer and uterus tumors.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
EPM5; PRIC2; PRIC2_HUMAN; Prickle homolog 2 (Drosophila); Prickle planar cell polarity protein 2; prickle-like 2 (Drosophila); prickle-like 2; Prickle-like protein 2; PRICKLE2
Target Background
This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5.
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