Recombinant Human Probable ATP-dependent RNA helicase DDX6 (DDX6)

Uniprot Id

P26196

Target Species

Human

Target Name

DDX6

Target Full Name

Probable ATP-dependent RNA helicase DDX6

Target Function

Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.

Target Involvement

A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Target Subcellular Location

Cytoplasm, P-body. Cytoplasm. Nucleus.

Target Protein Families

DEAD box helicase family, DDX6/DHH1 subfamily

Target Tissue Specificity

Abundantly expressed in most tissues.

Target Synonyms

DDX6; HLR2; RCK; Probable ATP-dependent RNA helicase DDX6; EC 3.6.4.13; ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK

Target Background

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified.