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Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1), Truncated

ACP04943

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Specifications

Cat.No	ACP04943	Target Name	HERC1
Target Synonyms	HERC1; Probable E3 ubiquitin-protein ligase HERC1; EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; p532; p619	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	3975-4360aa
Mol Weight	48.1 kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q15751

Background Information

Uniprot Id

Q15751
Target Species

Human
Target Name

HERC1
Target Full Name

Probable E3 ubiquitin-protein ligase HERC1
Target Function

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Target Involvement

Macrocephaly, dysmorphic facies, and psychomotor retardation (MDFPMR)
Target Subcellular Location

Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions.
Target Tissue Specificity

Widely expressed.
Target Research Area

Others
Target Synonyms

HERC1; Probable E3 ubiquitin-protein ligase HERC1; EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; p532; p619

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Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Probable E3 ubiquitin-protein ligase HERC1 (HERC1), Truncated Now

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