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| Cat.No | ACP07713 | Target Name | RNF217 |
|---|---|---|---|
| Target Synonyms | RNF217; C6orf172; IBRDC1; OSTL; E3 ubiquitin-protein ligase RNF217; IBR domain-containing protein 1; Opposite STL; RING finger protein 217 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8TC41 |
|---|
Uniprot Id
Q8TC41
Target Species
Human
Target Name
RNF217
Target Full Name
E3 ubiquitin-protein ligase RNF217
Target Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis.
Target Subcellular Location
Membrane; Single-pass membrane protein. Cytoplasm.
Target Protein Families
RBR family, RNF217 subfamily
Target Tissue Specificity
Mainly expressed in testis and skeletal muscle.
Target Synonyms
RNF217; C6orf172; IBRDC1; OSTL; E3 ubiquitin-protein ligase RNF217; IBR domain-containing protein 1; Opposite STL; RING finger protein 217
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