Recombinant Human Probable G-protein coupled receptor 151 (GPR151), Truncated

Uniprot Id

Q8TDV0

Target Species

Human

Target Name

GPR151

Target Full Name

G-protein coupled receptor 151

Target Function

Proton-sensing G-protein coupled receptor.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

High expression in the spinal cord.

Target Synonyms

GPR151; GALR4; GALRL; PGR7; G-protein coupled receptor 151; G-protein coupled receptor PGR7; GPCR-2037; Galanin receptor 4; Galanin-receptor-like protein; GalRL

Target Background

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.