Recombinant Human Probable methylthioribulose-1-phosphate dehydratase (APIP)

Uniprot Id

Q96GX9

Target Species

Human

Target Name

APIP

Target Full Name

Methylthioribulose-1-phosphate dehydratase

Target Function

Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Aldolase class II family, MtnB subfamily

Target Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.

Target Research Area

Cell Biology

Target Synonyms

Apaf1 Interacting Protein; APAF1-interacting protein; APIP; APIP2; CG129; CGI 29; CGI29; dJ179L10.2; MMRP19; Monocyte/macrophage protein 19; MTNB_HUMAN; MTRu 1 P dehydratase; MTRu-1-P dehydratase; Probable methylthioribulose 1 phosphate dehydratase; Probable methylthioribulose-1-phosphate dehydratase

Target Background

Enables identical protein binding activity; methylthioribulose 1-phosphate dehydratase activity; and zinc ion binding activity. Involved in several processes, including L-methionine salvage from methylthioadenosine; protein homotetramerization; and pyroptosis. Located in cytoplasm.