Recombinant Human Probable palmitoyltransferase ZDHHC8 (ZDHHC8), Truncated

Uniprot Id

Q9ULC8

Target Species

Human

Target Name

ZDHHC8

Target Full Name

Palmitoyltransferase ZDHHC8

Target Function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux. Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane. Could also play a role in glutamatergic transmission.

Target Subcellular Location

Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.

Target Protein Families

DHHC palmitoyltransferase family, ERF2/ZDHHC9 subfamily

Target Tissue Specificity

Widely expressed.

Target Synonyms

ZDHHC8; KIAA1292; ZDHHCL1; ZNF378; Palmitoyltransferase ZDHHC8; Zinc finger DHHC domain-containing protein 8; DHHC-8; Zinc finger protein 378

Target Background

This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.