Recombinant Human Probable phospholipid-transporting ATPase IB (ATP8A2), Truncated

Cat.No	ACP05785	Target Name	ATP8A2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05785

Target Name

ATP8A2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NTI2

Background Information

Uniprot Id

Q9NTI2
Target Species

Human
Target Name

ATP8A2
Target Full Name

Phospholipid-transporting ATPase IB
Target Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Target Involvement

Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4 (CMARQ4)
Target Subcellular Location

Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane. Photoreceptor inner segment.
Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Target Tissue Specificity

Strongly expressed in the brain, cerebellum, retina and testis.
Target Synonyms

AT8A2_HUMAN; ATP; Atp8a2; ATPase aminophospholipid transporter class I type 8A member 2; ATPase aminophospholipid transporter like class I type 8A member 2; ATPase class I type 8A member 2; ATPase phospholipid transporting 8A2; ATPIB; CAMRQ4; EC=3.6.3.1; IB; ML-1; ML1; P4 ATPase flippase complex alpha subunit ATP8A2; Probable phospholipid-transporting ATPase IB

Recombinant Human Probable phospholipid-transporting ATPase IB (ATP8A2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Probable phospholipid-transporting ATPase IB (ATP8A2), Truncated Now

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