Recombinant Human Probable phospholipid-transporting ATPase IC (ATP8B1), Truncated

Cat.No	ACP05392	Target Name	ATP8B1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05392

Target Name

ATP8B1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O43520

Background Information

Uniprot Id

O43520
Target Species

Human
Target Name

ATP8B1
Target Full Name

Phospholipid-transporting ATPase IC
Target Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane. Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts. Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2. Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1. Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Required for the preservation of cochlear hair cells in the inner ear. May act as cardiolipin transporter during inflammatory injury.
Target Involvement

Cholestasis, progressive familial intrahepatic, 1 (PFIC1); Cholestasis, benign recurrent intrahepatic, 1 (BRIC1); Cholestasis of pregnancy, intrahepatic 1 (ICP1)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Apical cell membrane. Cell projection, stereocilium. Endoplasmic reticulum. Golgi apparatus.
Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Target Tissue Specificity

Found in most tissues except brain and skeletal muscle. Most abundant in pancreas and small intestine.
Target Synonyms

AT8B1_HUMAN; ATP8B1; ATPase class I type 8B member 1; ATPase; aminophospholipid transporter; class I; type 8B; member 1; ATPIC; BRIC; E1-E2 ATPase; Familial intrahepatic cholestasis type 1; FIC1; OTTHUMP00000163615; PFIC; PFIC1; Phospholipid transporting ATPase IC; Probable phospholipid-transporting ATPase IC

Recombinant Human Probable phospholipid-transporting ATPase IC (ATP8B1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Probable phospholipid-transporting ATPase IC (ATP8B1), Truncated Now

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