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| Cat.No | ACP12987 | Target Name | TRUB1 |
|---|---|---|---|
| Target Synonyms | Probable tRNA pseudouridine synthase 1; PUS4; TruB pseudouridine (psi) synthase homolog 1 (E. coli); Trub1; TRUB1_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-349 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8WWH5 |
|---|
Uniprot Id
Q8WWH5
Target Species
Human
Target Name
TRUB1
Target Full Name
Pseudouridylate synthase TRUB1
Target Function
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs.
Target Subcellular Location
Nucleus. Cytoplasm, cytosol.
Target Protein Families
Pseudouridine synthase TruB family
Target Tissue Specificity
Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen.
Target Synonyms
Probable tRNA pseudouridine synthase 1; PUS4; TruB pseudouridine (psi) synthase homolog 1 (E. coli); Trub1; TRUB1_HUMAN
Target Background
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).
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