Recombinant Human Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (USP9Y), Truncated

Uniprot Id

O00507

Target Species

Human

Target Name

USP9Y

Target Full Name

Ubiquitin carboxyl-terminal hydrolase 9Y

Target Function

May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling

Target Involvement

Spermatogenic failure Y-linked 2 (SPGFY2)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Peptidase C19 family

Target Tissue Specificity

Widely expressed in embryonic and adult tissues.

Target Synonyms

AZF 1; AZF; AZF1; AZFA; Azoospermia factor 1; Deubiquitinating enzyme FAF Y; Deubiquitinating enzyme FAF-Y; DFFRY; Fat facets like; Fat facets like Drosophila; Fat facets protein related Y linked; Fat facets protein-related; Probable ubiquitin carboxyl terminal hydrolase FAF Y; Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; SP 3; SP3; SPGFY2; Ubiquitin specific peptidase 9 Y linked; Ubiquitin specific processing protease FAF Y; Ubiquitin specific protease 9 Y chromosome; Ubiquitin thioesterase FAF Y; Ubiquitin thiolesterase FAF-Y; Ubiquitin-specific protease 9; Ubiquitin-specific-processing protease FAF-Y; USP 10; USP 9Y; USP10; USP9Y; USP9Y_HUMAN; Y chromosome; Y-linked