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| Cat.No | ACP23453 | Target Name | PFN2 |
|---|---|---|---|
| Target Synonyms | D3S1319E; PFL; PFN 2; Pfn2; PROF2_HUMAN; Profilin II; Profilin-2; Profilin2; ProfilinII | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-140 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P35080 |
|---|
Uniprot Id
P35080
Target Species
Human
Target Name
PFN2
Target Full Name
Profilin-2
Target Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Target Subcellular Location
Cytoplasm, cytoskeleton.
Target Protein Families
Profilin family
Target Tissue Specificity
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Target Synonyms
D3S1319E; PFL; PFN 2; Pfn2; PROF2_HUMAN; Profilin II; Profilin-2; Profilin2; ProfilinII
Target Background
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
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