Recombinant Human Programmed cell death protein 1 (PDCD1), Truncated

This Recombinant Human PDCD1 protein is an essential research tool for cell biology studies. Programmed cell death protein 1 (PD-1), also known as CD279, is a key regulator of T-cell activation and immune tolerance, making it a crucial target in various immunological and cancer research applications. Our Recombinant Human PDCD1 protein is expressed in an E.coli system and features the extracellular domain (21-170aa) for optimal compatibility with a wide range of research assays. The N-terminal 6xHis-SUMO tag ensures effective purification and detection processes. With a purity greater than 90% as determined by SDS-PAGE, this protein delivers consistent and reliable results for your cell biology research. Available in both liquid and lyophilized powder forms, our Recombinant Human PDCD1 protein is designed to meet the diverse requirements of your scientific projects.

ACP03336

This Recombinant Human PDCD1 protein is an essential research tool for cell biology studies. Programmed cell death protein 1 (PD-1), also known as CD279, is a key regulator of T-cell activation and immune tolerance, making it a crucial target in various immunological and cancer research applications.
Our Recombinant Human PDCD1 protein is expressed in an E.coli system and features the extracellular domain (21-170aa) for optimal compatibility with a wide range of research assays. The N-terminal 6xHis-SUMO tag ensures effective purification and detection processes. With a purity greater than 90% as determined by SDS-PAGE, this protein delivers consistent and reliable results for your cell biology research. Available in both liquid and lyophilized powder forms, our Recombinant Human PDCD1 protein is designed to meet the diverse requirements of your scientific projects.

Number

Cat.No	ACP03336	Target Name	PDCD1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	21-170aa	Mol Weight	32.8kDa
Protein Length	Extracellular Domain	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03336

Target Name

PDCD1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

21-170aa

Mol Weight

32.8kDa

Protein Length

Extracellular Domain

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q15116

Background Information

Uniprot Id

Q15116
Target Species

Human
Target Name

PDCD1
Target Full Name

Programmed cell death protein 1
Target Function

Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.; The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Target Involvement

Systemic lupus erythematosus 2 (SLEB2)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Research Area

Cell Biology
Target Synonyms

CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1 ; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2 ; Systemic lupus erythematosus susceptibility 2
Target Background

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

Recombinant Human Programmed cell death protein 1 (PDCD1), Truncated

Specifications

Immunogen Information

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