Recombinant Human Prohibitin (PHB)

This Recombinant Human Prohibitin 1 (PHB1) protein is a valuable asset for your transcription research studies. Prohibitin 1 is a multifunctional protein involved in transcription regulation, apoptosis, and cell signaling. It plays a significant role in the cellular processes and serves as a potential target for various scientific investigations. Our Recombinant Human PHB1 protein is expressed in E.coli and features the full-length sequence (1-272aa) to support a wide range of research applications. The N-terminal 6xHis tag enables efficient purification and detection, ensuring a seamless integration into your experimental workflow. With a purity of greater than 90% as determined by SDS-PAGE, our PHB1 protein delivers consistent, reliable results for your research. Available in both liquid and lyophilized powder forms, our Recombinant Human Prohibitin 1 protein caters to the diverse needs of your transcription research projects.

ACP04297

This Recombinant Human Prohibitin 1 (PHB1) protein is a valuable asset for your transcription research studies. Prohibitin 1 is a multifunctional protein involved in transcription regulation, apoptosis, and cell signaling. It plays a significant role in the cellular processes and serves as a potential target for various scientific investigations.
Our Recombinant Human PHB1 protein is expressed in E.coli and features the full-length sequence (1-272aa) to support a wide range of research applications. The N-terminal 6xHis tag enables efficient purification and detection, ensuring a seamless integration into your experimental workflow. With a purity of greater than 90% as determined by SDS-PAGE, our PHB1 protein delivers consistent, reliable results for your research. Available in both liquid and lyophilized powder forms, our Recombinant Human Prohibitin 1 protein caters to the diverse needs of your transcription research projects.

Number

Cat.No	ACP04297	Target Name	PHB
Target Synonyms	Epididymis luminal protein 215; Epididymis secretory sperm binding protein Li 54e; HEL 215; HEL S 54e; PHB; PHB_HUMAN; PHB1; Prohibitin	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-272aa
Mol Weight	33.8kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04297

Target Name

PHB

Target Synonyms

Epididymis luminal protein 215; Epididymis secretory sperm binding protein Li 54e; HEL 215; HEL S 54e; PHB; PHB_HUMAN; PHB1; Prohibitin

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-272aa

Mol Weight

33.8kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P35232

Background Information

Uniprot Id

P35232
Target Species

Human
Target Name

PHB1
Target Full Name

Prohibitin 1
Target Function

Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.; In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Regulates mitochondrial respiration activity playing a role in cellular aging. The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6.; In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells.; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Target Subcellular Location

Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane.
Target Protein Families

Prohibitin family
Target Tissue Specificity

Widely expressed in different tissues.
Target Research Area

Transcription
Target Synonyms

Epididymis luminal protein 215; Epididymis secretory sperm binding protein Li 54e; HEL 215; HEL S 54e; PHB; PHB_HUMAN; PHB1; Prohibitin
Target Background

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Recombinant Human Prohibitin (PHB)

Specifications

Immunogen Information

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