Recombinant Human Prolactin receptor (PRLR), Truncated

Uniprot Id

P16471

Target Species

Human

Target Name

PRLR

Target Full Name

Prolactin receptor

Target Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Target Involvement

Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.; [Isoform 7]: Secreted.

Target Protein Families

Type I cytokine receptor family, Type 1 subfamily

Target Tissue Specificity

Expressed in breast, placenta, kidney, liver and pancreas.

Target Synonyms

PRLR; Prolactin receptor; PRL-R

Target Background

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.