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Recombinant human prostatic acid phosphatase (ACP3) is successfully expressed in E.coli using a suitable expression vector. The expression construct is designed to encode the specific region spanning amino acids 33 to 382 of the human ACP3 protein. To aid in purification and detection, an N-terminal 10xHis-tag is incorporated into the vector construct. The production process results in a high-purity recombinant ACP3 protein, with a purity level of up to 90% confirmed by SDS-PAGE analysis. When visualized on the gel, the purified protein appears as a distinct band with an estimated molecular weight of approximately 44 kDa.
Recombinant human prostatic acid phosphatase (ACP3) is successfully expressed in E.coli using a suitable expression vector. The expression construct is designed to encode the specific region spanning amino acids 33 to 382 of the human ACP3 protein. To aid in purification and detection, an N-terminal 10xHis-tag is incorporated into the vector construct. The production process results in a high-purity recombinant ACP3 protein, with a purity level of up to 90% confirmed by SDS-PAGE analysis. When visualized on the gel, the purified protein appears as a distinct band with an estimated molecular weight of approximately 44 kDa.
| Cat.No | ACP01327 | Target Name | ACP3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 33-382aa | Mol Weight | 46.7 kDa |
| Protein Length | Partial of Isoform 2 | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P15309 |
|---|
Uniprot Id
P15309
Target Species
Human
Target Name
ACP3
Target Full Name
Prostatic acid phosphatase
Target Function
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.; Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor.; (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
Target Subcellular Location
[Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol.
Target Protein Families
Histidine acid phosphatase family
Target Tissue Specificity
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceou
Target Research Area
Cancer
Target Synonyms
ACPP; 5'-NT; ACP-3; TM-PAP; Prostatic Acid Phosphatase (ACPP)
Target Background
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway.
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