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| Cat.No | ACP10890 | Target Name | GID8 |
|---|---|---|---|
| Target Synonyms | GID8; C20orf11; TWA1Glucose-induced degradation protein 8 homolog; Two hybrid-associated protein 1 with RanBPM; Twa1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-228 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NWU2 |
|---|
Uniprot Id
Q9NWU2
Target Species
Human
Target Name
GID8
Target Full Name
Glucose-induced degradation protein 8 homolog
Target Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
GID8 family
Target Tissue Specificity
Up-regulated in colorectal cancer tissues (at protein level).
Target Synonyms
GID8; C20orf11; TWA1Glucose-induced degradation protein 8 homolog; Two hybrid-associated protein 1 with RanBPM; Twa1
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