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The expression region of this recombinant Human PDIA3 covers amino acids 25-505. The theoretical molecular weight of the PDIA3 protein is 59.3 kDa. This protein is generated in a e.coli-based system. The PDIA3 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant PDIA3 protein in following stages of expression and purification.Protein disulfide-isomerase A3 (PDIA3), also known as endoplasmic reticulum protein 57 (ERp57), is a member of the protein disulfide-isomerase (PDI) family. PDIA3 plays a crucial role in protein folding and quality control within the endoplasmic reticulum (ER), where it aids in the formation and rearrangement of disulfide bonds in newly synthesized proteins. As a thiol-disulfide oxidoreductase, PDIA3 contributes to the correct folding of glycoproteins and helps maintain ER homeostasis. It interacts with major histocompatibility complex class I (MHC-I) molecules, facilitating their assembly and transport to the cell surface for antigen presentation. PDIA3 is also involved in various cellular processes, including regulation of apoptosis and modulation of cell signaling pathways. Research on PDIA3 encompasses its roles in protein folding, ER stress response, immune system function, and its implications in diseases such as cancer and neurodegenerative disorders.
The expression region of this recombinant Human PDIA3 covers amino acids 25-505. The theoretical molecular weight of the PDIA3 protein is 59.3 kDa. This protein is generated in a e.coli-based system. The PDIA3 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant PDIA3 protein in following stages of expression and purification.Protein disulfide-isomerase A3 (PDIA3), also known as endoplasmic reticulum protein 57 (ERp57), is a member of the protein disulfide-isomerase (PDI) family. PDIA3 plays a crucial role in protein folding and quality control within the endoplasmic reticulum (ER), where it aids in the formation and rearrangement of disulfide bonds in newly synthesized proteins. As a thiol-disulfide oxidoreductase, PDIA3 contributes to the correct folding of glycoproteins and helps maintain ER homeostasis. It interacts with major histocompatibility complex class I (MHC-I) molecules, facilitating their assembly and transport to the cell surface for antigen presentation. PDIA3 is also involved in various cellular processes, including regulation of apoptosis and modulation of cell signaling pathways. Research on PDIA3 encompasses its roles in protein folding, ER stress response, immune system function, and its implications in diseases such as cancer and neurodegenerative disorders.
| Cat.No | ACP03596 | Target Name | PDIA3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 25-505aa | Mol Weight | 59.3 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P30101 |
|---|
Uniprot Id
P30101
Target Species
Human
Target Name
PDIA3
Target Full Name
Protein disulfide-isomerase A3
Target Subcellular Location
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome.
Target Protein Families
Protein disulfide isomerase family
Target Tissue Specificity
Detected in the flagellum and head region of spermatozoa (at protein level). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level).
Target Research Area
Signal Transduction
Target Synonyms
58 kDa glucose regulated protein; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER 60; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER p57; ER protein 57; ER protein 60; ERp 57; ERp57; ERp60; ERp61; Glucose Regulated Protein 58 Kd; GRP 57; GRP 58; GRP57; HsT17083; p58; PDIA 3; PDIA3; PDIA3_HUMAN; Phospholipase C alpha; PI PLC; Protein disulfide isomerase A3; Protein disulfide isomerase family A member 3; Protein disulfide-isomerase A3
Target Background
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates.
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