Recombinant Human Protein ETHE1, mitochondrial (ETHE1)

Cat.No	ACP03431	Target Name	ETHE1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	8-254aa	Mol Weight	43.1kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03431

Target Name

ETHE1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

8-254aa

Mol Weight

43.1kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O95571

Background Information

Uniprot Id

O95571
Target Species

Human
Target Name

ETHE1
Target Full Name

Persulfide dioxygenase ETHE1, mitochondrial
Target Function

Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
Target Involvement

Ethylmalonic encephalopathy (EE)
Target Subcellular Location

Cytoplasm. Nucleus. Mitochondrion matrix.
Target Protein Families

Metallo-beta-lactamase superfamily, Glyoxalase II family
Target Tissue Specificity

Ubiquitously expressed.
Target Research Area

Cell Biology
Target Synonyms

Ethe1; ETHE1 protein; mitochondrial precursor; ETHE1_HUMAN; ethylmalonic encephalopathy 1; Ethylmalonic encephalopathy protein 1; hepatoma subtracted clone one; Hepatoma subtracted clone one protein; HSCO; mitochondrial; Protein ETHE1; Protein ETHE1 mitochondrial; YF13H12
Target Background

This gene encodes a member of the metallo beta-lactamase family of iron-containing proteins involved in the mitochondrial sulfide oxidation pathway. The encoded protein catalyzes the oxidation of a persulfide substrate to sulfite. Certain mutations in this gene cause ethylmalonic encephalopathy, an infantile metabolic disorder affecting the brain, gastrointestinal tract and peripheral vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Recombinant Human Protein ETHE1, mitochondrial (ETHE1)

Specifications

Immunogen Information

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