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| Cat.No | ACP07306 | Target Name | RETREG1 |
|---|---|---|---|
| Target Synonyms | RETREG1; FAM134B; JK1; Reticulophagy regulator 1; Reticulophagy receptor 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H6L5 |
|---|
Uniprot Id
Q9H6L5
Target Species
Human
Target Name
RETREG1
Target Full Name
Reticulophagy regulator 1
Target Function
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons.
Target Involvement
Neuropathy, hereditary sensory and autonomic, 2B (HSAN2B)
Target Subcellular Location
Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
RETREG family
Target Tissue Specificity
Overexpressed in esophageal squamous cell carcinoma.
Target Synonyms
RETREG1; FAM134B; JK1; Reticulophagy regulator 1; Reticulophagy receptor 1
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