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| Cat.No | ACP16044 | Target Name | BRINP3 |
|---|---|---|---|
| Target Synonyms | BRINP3; DBCCR1L; DBCCR1L1; FAM5CBMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 34-766 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q76B58 |
|---|
Uniprot Id
Q76B58
Target Species
Human
Target Name
BRINP3
Target Full Name
BMP/retinoic acid-inducible neural-specific protein 3
Target Function
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
Target Subcellular Location
Secreted. Mitochondrion.
Target Protein Families
BRINP family
Target Tissue Specificity
Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
Target Synonyms
BRINP3; DBCCR1L; DBCCR1L1; FAM5CBMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1
Target Background
This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene.
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