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| Cat.No | ACP12821 | Target Name | FAM89B |
|---|---|---|---|
| Target Synonyms | FAM89B; Lrap25; Leucine repeat adapter protein 25 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-189 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N5H3 |
|---|
Uniprot Id
Q8N5H3
Target Species
Human
Target Name
FAM89B
Target Full Name
Leucine repeat adapter protein 25
Target Function
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
Target Subcellular Location
[Isoform 3]: Cytoplasm. Cell projection, lamellipodium.
Target Protein Families
FAM89 family
Target Synonyms
FAM89B; Lrap25; Leucine repeat adapter protein 25
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