Recombinant Human Protein fem-1 homolog C (FEM1C)

Uniprot Id

Q96JP0

Target Species

Human

Target Name

FEM1C

Target Full Name

Protein fem-1 homolog C

Target Function

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. Promotes ubiquitination and degradation of SLBP

Target Protein Families

Fem-1 family

Target Tissue Specificity

Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.

Target Synonyms

EUROIMAGE686608; EUROIMAGE783647 ; fem1 homolog c (C. elegans); FEM1-gamma; FEM1A; FEM1c; FEM1C_HUMAN; Feminization 1 homolog a; KIAA1785; Protein fem-1 homolog C