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| Cat.No | ACP00160 | Target Name | FOSB |
|---|---|---|---|
| Target Synonyms | AP-1 transcription factor subunit;G0/G1 switch regulatory protein 3;Transcription factor AP-1 subunit FosB, FosB proto-oncogene | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-338aa |
| Mol Weight | 40.0 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P53539 |
|---|
Uniprot Id
P53539
Target Species
Human
Target Name
FOSB
Target Full Name
Protein FosB
Target Function
FosB interacts with Jun proteins enhancing their DNA binding activity.
Target Subcellular Location
Nucleus.
Target Protein Families
BZIP family, Fos subfamily
Target Research Area
Cancer
Target Synonyms
Activator protein 1; AP 1; DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; fosB; FOSB_HUMAN; G0/G1 switch regulatory protein 3; G0S3; GOS 3; GOS B; GOS3; GOSB; MGC42291; Oncogene FOS B; Oncogene FOSB; Protein fos B; Protein fosB
Target Background
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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