Recombinant human protein homolog 1

Cat.No	ACP20438	Target Name	HOMER1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-354aa	Mol Weight	67.7kD
Protein Length	Full length	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP20438

Target Name

HOMER1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-354aa

Mol Weight

67.7kD

Protein Length

Full length

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q86YM7

Background Information

Uniprot Id

Q86YM7
Target Species

Human
Target Name

HOMER1
Target Full Name

Homer protein homolog 1
Target Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Target Subcellular Location

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, dendritic spine.
Target Protein Families

Homer family
Target Research Area

Neuroscience
Target Synonyms

HOME1_HUMAN; Homer ; HOMER 1A; HOMER 1B ; HOMER 1C; Homer homolog 1 (Drosophila); homer homolog 1; Homer protein homolog 1; homer scaffolding protein 1; Homer; Drosophila; homolog of; 1; Homer; neuronal immediate early gene; 1 ; Homer-1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47 ; Ves 1
Target Background

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.

Recombinant human protein homolog 1

Specifications

Immunogen Information

Inquire Recombinant human protein homolog 1 Now

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