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| Cat.No | ACP18577 | Target Name | INCA1 |
|---|---|---|---|
| Target Synonyms | HSD45; Inca1; INCA1_HUMAN; Inhibitor of CDK cyclin A1 interacting protein 1; Inhibitor of CDK interacting with cyclin A1; MGC148150; MGC148151; Protein INCA1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-236 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q0VD86 |
|---|
Uniprot Id
Q0VD86
Target Species
Human
Target Name
INCA1
Target Full Name
Protein INCA1
Target Function
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
INCA family
Target Tissue Specificity
Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors. Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells.
Target Synonyms
HSD45; Inca1; INCA1_HUMAN; Inhibitor of CDK cyclin A1 interacting protein 1; Inhibitor of CDK interacting with cyclin A1; MGC148150; MGC148151; Protein INCA1
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