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| Cat.No | ACP10052 | Target Name | INTU |
|---|---|---|---|
| Target Synonyms | Homolog of inturned (X. tropicalis); INT; intu; Inturned planar cell polarity effector homolog; KIAA1284; PDZ domain containing 6; PDZ domain-containing protein 6; PDZD 6; PDZD6_HUMAN; PDZK6 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9ULD6 |
|---|
Uniprot Id
Q9ULD6
Target Species
Human
Target Name
INTU
Target Full Name
Protein inturned
Target Function
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies.
Target Subcellular Location
Cytoplasm. Cell surface. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
Inturned family
Target Synonyms
Homolog of inturned (X. tropicalis); INT; intu; Inturned planar cell polarity effector homolog; KIAA1284; PDZ domain containing 6; PDZ domain-containing protein 6; PDZD 6; PDZD6_HUMAN; PDZK6
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