Recombinant Human Protein Jade-1 (PHF17), Truncated

Uniprot Id

Q6IE81

Target Species

Human

Target Name

JADE1

Target Full Name

Protein Jade-1

Target Function

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.

Target Subcellular Location

Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body.

Target Protein Families

JADE family

Target Tissue Specificity

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.

Target Synonyms

FLJ22479; Gene for apoptosis and differentiation in epithelia; Jade family PHD finger 1; JADE1 ; JADE1_HUMAN; KIAA1807 ; OTTHUMP00000219842; OTTHUMP00000219934; OTTHUMP00000219935; OTTHUMP00000219936; PHD finger protein 17; PHD protein Jade 1; Phf17; Protein Jade 1; Protein Jade-1

Target Background

Enables transcription coactivator activity. Involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including ciliary basal body; cytosol; and nuclear speck. Part of histone acetyltransferase complex.