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| Cat.No | ACP15101 | Target Name | WWC1 |
|---|---|---|---|
| Target Synonyms | WWC1; KIAA0869; Protein KIBRA; HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IX03 |
|---|
Uniprot Id
Q8IX03
Target Species
Human
Target Name
WWC1
Target Full Name
Protein KIBRA
Target Function
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.
Target Protein Families
WWC family, KIBRA subfamily
Target Tissue Specificity
Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cere
Target Synonyms
WWC1; KIAA0869; Protein KIBRA; HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1
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