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| Cat.No | ACP12481 | Target Name | NELL2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 22-816 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99435 |
|---|
Uniprot Id
Q99435
Target Species
Human
Target Name
NELL2
Target Full Name
Protein kinase C-binding protein NELL2
Target Function
Required for neuron survival through the modulation of MAPK pathways. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty.
Target Subcellular Location
Secreted.
Target Synonyms
A330108N19Rik; Mel91; MEL91 protein; NEL like 2 (chicken); NEL-like protein 2; Nel-related protein 2; NELL2; NELL2_HUMAN; Neural epidermal growth factor like 2; NRP2; Protein kinase C-binding protein NELL2; R75516
Target Background
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis.
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