Recombinant Human Protein kinase C delta-binding protein (PRKCDBP)

Uniprot Id

Q969G5

Target Species

Human

Target Name

CAVIN3

Target Full Name

Caveolae-associated protein 3

Target Function

Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.

Target Subcellular Location

Cytoplasm. Membrane, caveola. Cytoplasm, cytosol.

Target Protein Families

CAVIN family

Target Tissue Specificity

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.

Target Synonyms

Cavin 3; Cavin-3; CAVIN3; hSRBC; MGC20400; PRDBP_HUMAN; Prkcdbp; Protein kinase C delta binding protein; Protein kinase C delta-binding protein; Sdr related gene product that binds to c kinase; Serum deprivation response factor related gene product that binds to C kinase; Serum deprivation response factor-related gene product that binds to C-kinase; SRBC

Target Background

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein.