Recombinant Human Protein LSM14 homolog A (LSM14A)

Uniprot Id

Q8ND56

Target Species

Human

Target Name

LSM14A

Target Full Name

Protein LSM14 homolog A

Target Function

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.

Target Subcellular Location

Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule.

Target Protein Families

LSM14 family

Target Synonyms

AlphaSNBP; C19orf13 ; Chromosome 19 open reading frame 13 ; DKFZp434D1335; FAM61A; Family with sequence similarity 61 member A; hRAP55; hRAP55A; LS14A_HUMAN; LSM14 homolog A (SCD6 S cerevisiae); LSM14 homolog A; LSM14A; Protein FAM61A; Protein LSM14 homolog A; Protein SCD6 homolog; Putative alpha synuclein binding protein ; Putative alpha-synuclein-binding protein; RAP55; RNA associated protein 55 ; RNA-associated protein 55A; SCD6 homolog A (S cerevisiae)

Target Background

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.