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| Cat.No | ACP12956 | Target Name | NKD1 |
|---|---|---|---|
| Target Synonyms | NKD1; NKD; PP7246; Protein naked cuticle homolog 1; Naked-1; hNkd; hNkd1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-470 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q969G9 |
|---|
Uniprot Id
Q969G9
Target Species
Human
Target Name
NKD1
Target Full Name
Protein naked cuticle homolog 1
Target Function
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
Target Subcellular Location
Cell membrane. Cytoplasm.
Target Protein Families
NKD family
Target Tissue Specificity
Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.
Target Synonyms
NKD1; NKD; PP7246; Protein naked cuticle homolog 1; Naked-1; hNkd; hNkd1
Target Background
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
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