Recombinant Human Protein NDRG2 (NDRG2)

Uniprot Id

Q9UN36

Target Species

Human

Target Name

NDRG2

Target Full Name

Protein NDRG2

Target Function

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Target Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone.

Target Protein Families

NDRG family

Target Tissue Specificity

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. E

Target Synonyms

Antidepressant related protein ADRG123; Cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N myc downstream regulated gene 2; N myc downstream regulator 2; NDR1 related protein NDR2; NDRG 2; NDRG family member 2; NDRG1 related protein; NDRG2; NDRG2_HUMAN; Protein NDRG2; Protein Syld709613; SYLD; Syld709613 protein

Target Background

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants.