Recombinant Human Protein phosphatase 1 regulatory subunit 3B (PPP1R3B)

Uniprot Id

Q86XI6

Target Species

Human

Target Name

PPP1R3B

Target Full Name

Protein phosphatase 1 regulatory subunit 3B

Target Function

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.

Target Tissue Specificity

Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expr

Target Synonyms

FLJ14005; FLJ34675; GL; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL ; Hepatic glycogen targeting subunit G(L); Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; PP1 subunit R4; Ppp1r3b; PPP1R4; PPR3B_HUMAN; Protein phosphatase 1 regulatory (inhibitor) subunit 3B; Protein phosphatase 1 regulatory subunit 3B; Protein phosphatase 1 regulatory subunit 4; Protein phosphatase 1 subunit 4; Protein phosphatase 1 subunit GL; PTG; R4

Target Background

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.