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Recombinant Human Protein prune homolog (PRUNE)

ACP04269

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Specifications

Cat.No	ACP04269	Target Name	PRUNE1
Target Synonyms	DRES-17; DRES17; Drosophila-related expressed sequence 17; hPrune; HTcD37; Protein prune homolog; PRUNE; Prune homolog; PRUNE like protein; PRUNE_HUMAN; TcD37 homolog	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-168aa
Mol Weight	22.5kDa	Protein Length	Full Length of Isoform 6
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q86TP1

Background Information

Uniprot Id

Q86TP1
Target Species

Human
Target Name

PRUNE1
Target Full Name

Exopolyphosphatase PRUNE1
Target Function

Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.
Target Involvement

Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA)
Target Subcellular Location

Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Target Protein Families

PPase class C family, Prune subfamily
Target Tissue Specificity

Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
Target Research Area

Cancer
Target Synonyms

DRES-17; DRES17; Drosophila-related expressed sequence 17; hPrune; HTcD37; Protein prune homolog; PRUNE; Prune homolog; PRUNE like protein; PRUNE_HUMAN; TcD37 homolog

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Recombinant Human Protein prune homolog (PRUNE)

Specifications

Immunogen Information

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