Recombinant Human Protein-S-isoprenylcysteine O-methyltransferase (ICMT), Truncated

Uniprot Id

O60725

Target Species

Human

Target Name

ICMT

Target Full Name

Protein-S-isoprenylcysteine O-methyltransferase

Target Function

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

Class VI-like SAM-binding methyltransferase superfamily, Isoprenylcysteine carboxyl methyltransferase family

Target Tissue Specificity

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

Target Synonyms

1700008E11Rik; C80758; fcmt; Gm13095; HSTE14; Icmt; ICMT_HUMAN; Isoprenylcysteine carboxylmethyltransferase; MGC118506; MGC39955 ; MGC95322; MST098; MSTP098; OTTMUSG00000010406; pcCMT; PCMT; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; Protein-S-isoprenylcysteine O-methyltransferase; RP23-421E12.4; STE14

Target Background

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.