Recombinant Human Protein SON (SON), Truncated

Uniprot Id

P18583

Target Species

Human

Target Name

SON

Target Full Name

Protein SON

Target Function

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1

Target Involvement

ZTTK syndrome (ZTTKS)

Target Subcellular Location

Nucleus speckle. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.

Target Tissue Specificity

Widely expressed, with the higher expression seen in leukocyte and heart.

Target Synonyms

BASS1; Bax antagonist selected in saccharomyces 1; DBP-5; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; Protein SON; SON; SON protein; SON_HUMAN; SON3