Recombinant Human Protein sprouty homolog 4 (SPRY4)

Uniprot Id

Q9C004

Target Species

Human

Target Name

SPRY4

Target Full Name

Protein sprouty homolog 4

Target Function

Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin.

Target Involvement

Hypogonadotropic hypogonadism 17 with or without anosmia (HH17)

Target Subcellular Location

Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Sprouty family

Target Synonyms

Protein sprouty homolog 4; Sprouty 4; Sprouty homolog 4; sprouty homolog 4 (Drosophila); SPRY 4; Spry-4; Spry4; SPY4_HUMAN

Target Background

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants.