Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP12212 | Target Name | NUDT16L1 |
|---|---|---|---|
| Target Synonyms | NUDT16L1; SDOS; TIRR; Tudor-interacting repair regulator protein; NUDT16-like protein 1; Protein syndesmos | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-211 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BRJ7 |
|---|
Uniprot Id
Q9BRJ7
Target Species
Human
Target Name
NUDT16L1
Target Full Name
Tudor-interacting repair regulator protein
Target Function
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA
Target Subcellular Location
Nucleus.
Target Protein Families
Nudix hydrolase family, TIRR subfamily
Target Synonyms
NUDT16L1; SDOS; TIRR; Tudor-interacting repair regulator protein; NUDT16-like protein 1; Protein syndesmos
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
