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| Cat.No | ACP16642 | Target Name | SZT2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5T011 |
|---|
Uniprot Id
Q5T011
Target Species
Human
Target Name
SZT2
Target Full Name
KICSTOR complex protein SZT2
Target Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. May play a role in the cellular response to oxidative stress.
Target Involvement
Epileptic encephalopathy, early infantile, 18 (EIEE18)
Target Subcellular Location
Lysosome membrane. Peroxisome.
Target Tissue Specificity
Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia. Expressed in peripheral white blood cells.
Target Synonyms
Chromosome 1 open reading frame 84; FLJ34502; Hypothetical protein LOC23334 ; Protein SZT2; RP11-506B15.1; Seizure threshold 2 homolog A; Seizure threshold 2 protein homolog; SZT2; SZT2_HUMAN; SZT2A; Uncharacterized protein KIAA0467
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