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| Cat.No | ACP13132 | Target Name | THEMIS |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-641 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N1K5 |
|---|
Uniprot Id
Q8N1K5
Target Species
Human
Target Name
THEMIS
Target Full Name
Protein THEMIS
Target Function
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Themis family
Target Synonyms
C6orf190; C6orf207; MGC163388; Protein THEMIS; SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS; SPOT; THEMIS; THMS1_HUMAN; Thymocyte expressed molecule involved in selection; Thymocyte selection associated; Thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA
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